[HTML][HTML] High prevalence of genotypes associated with sulfadoxine/pyrimethamine resistance in the rural area of Fougamou, Gabon
FM Boukoumba, JB Lekana-Douki, PB Matsiegui… - Journal of Global …, 2021 - Elsevier
… Plasmodium falciparum dihydropteroate synthase (Pfdhps) and … Clinical trials to investigate
the efficacy of IPT-SP are much … Pyrimethamine binds far more strongly to the parasite DHFR …
the efficacy of IPT-SP are much … Pyrimethamine binds far more strongly to the parasite DHFR …
[HTML][HTML] Assessment of genetic polymorphisms associated with malaria antifolate resistance among the population of Libreville, Gabon
SD Dinzouna-Boutamba, BA Iroungou, FL Akombi… - Malaria Journal, 2023 - Springer
… (AL), and sulfadoxine–pyrimethamine (SP) has been the … -level resistance toward
pyrimethamine. Additive mutations at … T, which is associated with cycloguanil resistance, in the …
pyrimethamine. Additive mutations at … T, which is associated with cycloguanil resistance, in the …
Prevalence of Mutant Dihydrofolate Reductase Gene (DHFR) and Its Implication on Pyrimethamine Resistance in Rural Kwara State, Nigeria
OK Adebobola - 2021 - search.proquest.com
… Resistance to Sulfadoxine-Pyrimethamine is mediated by … of efficacy of core inhibitors
of this class like pyrimethamine … (PG; metabolized in vivo to the active form cycloguanil [CG]) …
of this class like pyrimethamine … (PG; metabolized in vivo to the active form cycloguanil [CG]) …
[HTML][HTML] Widespread resistance mutations to sulfadoxine-pyrimethamine in malaria parasites imported to China from Central and Western Africa
L Zhao, L Pi, Y Qin, Y Lu, W Zeng, Z Xiang, P Qin… - International Journal for …, 2020 - Elsevier
… mutations eroding the efficacy of sulfadoxine-pyrimethamine (SP)… We report for the first time
mutation I164L-dhfr and I431V-dhps in … For genotypes of Pfdhfr, five kinds of genotypes were …
mutation I164L-dhfr and I431V-dhps in … For genotypes of Pfdhfr, five kinds of genotypes were …
[HTML][HTML] Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of …
… (Pfdhps) genes confer resistance to pyrimethamine and … of SP efficacy studies for
intermittent preventive treatment in … Currently, sulfadoxine-pyrimethamine (SP) is the only anti-…
intermittent preventive treatment in … Currently, sulfadoxine-pyrimethamine (SP) is the only anti-…
[HTML][HTML] Molecular Surveillance and in vitro drug sensitivity study of Plasmodium falciparum isolates from the China–Myanmar border
S Wang, S Xu, J Geng, Y Si, H Zhao, X Li… - The American Journal …, 2020 - ncbi.nlm.nih.gov
… in malaria parasites is monitored through clinical efficacy … sulfadoxine and pyrimethamine
(PY) are well understood and … Through in vitro drug assays and genotyping of drug resistance–…
(PY) are well understood and … Through in vitro drug assays and genotyping of drug resistance–…
[HTML][HTML] P. falciparum and Its Molecular Markers of Resistance to Antimalarial Drugs
P Hodoameda - Plasmodium species and drug resistance, 2021 - intechopen.com
… DHFR are associated with resistance to pyrimethamine and cycloguanil, while mutations in
DHPS are … been associated with decreased susceptibility to sulfadoxine-pyrimethamine [65]. …
DHPS are … been associated with decreased susceptibility to sulfadoxine-pyrimethamine [65]. …
Transmission Efficiency of Plasmodium falciparum Malaria Resistant Strains in the African Mosquito Vectors
EM Sarah-Matio - 2021 - theses.hal.science
… to the sulphadoxine - pyrimethamine. More so, we did … in asymptomatics, that showed that
resistant genotypes persist at … treatment, while amodiaquine/ sulfadoxine-pyrimethamine (AQ/…
resistant genotypes persist at … treatment, while amodiaquine/ sulfadoxine-pyrimethamine (AQ/…
[HTML][HTML] Different In Vitro Drug Susceptibility Profile of Plasmodium falciparum Isolates from Two Adjacent Areas of Northeast Myanmar and Molecular Markers for …
M Duan, Y Bai, S Deng, Y Ruan, W Zeng, X Li… - Tropical Medicine and …, 2022 - mdpi.com
… to chloroquine and pyrimethamine but relatively sensitive to … and used for in vitro drug
assay and genotyping [13]. Frozen … first ACT introduced, but its efficacy steadily declined in the …
assay and genotyping [13]. Frozen … first ACT introduced, but its efficacy steadily declined in the …
[HTML][HTML] Malaria chemoprevention and drug resistance: a review of the literature and policy implications
CV Plowe - Malaria Journal, 2022 - Springer
… Pyrimethamine and other antifolates such as proguanil (via its metabolite cycloguanil) and
trimethoprim target P… those that rely on the antifolate drug sulfadoxine-pyrimethamine (SP). In …
trimethoprim target P… those that rely on the antifolate drug sulfadoxine-pyrimethamine (SP). In …